Full list of technical support documents (TSDs)

TSD 27: Prioritising studies and outcomes for consideration in NICE HealthTech literature reviews 

TSD 26: Expert elicitation for long-term survival outcomes

TSD 25: Evidence Synthesis of Diagnostic Test Accuracy for Decision Making

TSD 24: Adjusting survival time estimates in the presence of treatment switching [Update of TSD16]

TSD 23: A guide to calculating severity shortfall for NICE evaluations (updated Sept 2026)

TSD 22: Mapping to estimate health state utilities (Updated Sept 2026) 

TSD 21: Flexible methods for survival analysis

TSD 20: Multivariate meta-analysis of summary data for combining treatment effects on correlated outcomes and evaluating surrogate endpoints

TSD 19: Partitioned survival analysis as a decision modelling tool

TSD 18: Methods for population-adjusted indirect comparisons in submissions to NICE

TSD 17: The use of observational data to inform estimates of treatment effectiveness in technology appraisal: Methods for comparative individual patient data

TSD 16: Adjusting survival time estimates in the presence of treatment switching

TSD 15: Cost-effectiveness modelling using patient-level simulation

TSD 14: Survival analysis for economic evaluations alongside clinical trials – extrapolation with patient-level data

TSD 13: Identifying and reviewing evidence to inform the conceptualisation and population of cost-effectiveness models

TSD 12: The use of health state utility values in decision models

TSD 11: Alternatives to EQ-5D for generating health state utility values

TSD 10: The use of mapping methods to estimate health state utility values

TSD 9: The identification, review and synthesis of health state utility values from the literature

TSD 8: An introduction to the measurement and valuation of health for NICE submissions 

TSD 7: Evidence synthesis of treatment efficacy in decision making: a reviewer’s checklist 

TSD 6: Embedding evidence synthesis in probabilistic cost effectiveness analysis: Software choices 

TSD 5: Evidence synthesis in the baseline natural history model 

TSD 4: Inconsistency in networks of evidence based on randomised controlled trials 

TSD 3: Heterogeneity: subgroups, meta-regression, bias and bias-adjustment 

TSD 2: A general linear modelling framework for pair-wise and network meta-analysis of randomised controlled trials 

TSD 1: Introduction to evidence synthesis for decision making